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Incidence of bacteraemia in HIV-infected children in Africa, and the impact of highly active antiretroviral therapy

Includes abstract. / Includes bibliographical references. / From November 2002 to December 2006, a placebo-controlled, randomized trial investigated the incidence of tuberculosis and the overall mortality in a cohort of HIV-infected children in Cape Town, South Africa. They were randomized to receive either Isoniazid Preventive Therapy (IPT) or placebo. In addition, they were randomized to receive trimethoprim/sulfamethoxaxole prophylaxis on either a daily or a three-times-per-week schedule. The aim: To describe the incidence of bacteraemia, and the spectrum of organisms cultured. To determine if there was a difference in the incidence of bacteraemia between children using Isoniazid Preventive Therapy (IPT) versus placebo; and to determine if there was a difference in the incidence of bacteraemias between the groups using daily versus thrice-weekly trimethoprim/sulphamethoxazole prophylaxis.

Identiferoai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uct/oai:localhost:11427/11483
Date January 2010
CreatorsLe Roux, David Martin
ContributorsZar, Heather
PublisherUniversity of Cape Town, Faculty of Health Sciences, Department of Paediatrics and Child Health
Source SetsSouth African National ETD Portal
LanguageEnglish
Detected LanguageEnglish
TypeMaster Thesis, Masters, MMed
Formatapplication/pdf

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