<p dir="ltr">My research projects focuses on the dual targeting of small molecules to abrogate aberrant α-syn, tau (2N4R), and p-tau (1N4R) aggregation and to reduce the spread of AD and related dementias. Not very many drug discovery programs focus on the specific isoforms of the tau protein. We established two series of compounds: aminoindole compounds connected by a carboxamide and triazine compounds connected by a triazine linker. Using biophysical methods we evaluated the effectiveness of both series of compounds in decreasing the amount of misfolded α-syn and tau protein in order to explore their anti-aggregation potential.</p><p><br></p>
| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/25685910 |
| Date | 06 May 2024 |
| Creators | Eduardo Ramirez (18436542) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/thesis/EVALUATION_OF_AMINOINDOLE_CARBOXAMIDES_AND_TRIAZINES_AS_POTENTIAL_ANTI-AGGREGATION_AGENTS_OF_PROTEIN_MISFOLDING_DISEASES/25685910 |
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