Title: An assessment of the effectiveness of Andolex-C ® mouth rinse on oral palliation
in HIV-infected patients.
Background: The majority of HIV-infected patients present with oral lesions associated
with the disease. HIV-infected patients experience profound disorders like oral infections
and ulcerations, discomfort and greater levels of social impact than non-HIV patients as a
result of oral lesions. Studies have indicated that mouth pain is a significant symptom
reported by HIV-infected patients. In order to relieve pain and discomfort and improve
quality of life, management of HIV-infected patients should include relief of mouth pain,
discomfort as well as the social and psychological distress caused by the oral lesions.
Objectives: To determine the prevalence of oral lesions associated with HIV among a
cohort of HIV-infected patients. To assess the effectiveness of Andolex-C® mouth rinse
on oral palliation in HIV-infected patients.
Methods: The intervention of Andolex C® mouth rinse plus a proven preventive oral
hygiene regimen was compared to an established oral hygiene intervention. Two hundred
and ninety nine patients were randomly assigned into Groups 1 and 2. Patients in Group
1 were given toothbrushes and toothpaste and oral hygiene instruction ‘routine oral
hygiene package’. Those in Group 2 received Andolex-C® mouth rinse in addition to the
‘routine oral hygiene package’ given to the first group. A baseline assessment of mouth
pain and/or discomfort was done via a clinical examination and an assessment of quality
of life was done using the Oral Health Impact Profile (OHIP) questionnaire. The
intervention was carried out over a four week period after which a follow-up assessment
was done using the same tools. Comparison of baseline versus post-treatment scores was
performed to determine impact of intervention in both groups.
Results: The prevalence of combined candidal lesions was 71.6% of which
Pseudomembranous candidiasis was 43.2%. Erythematous candidiasis and angular
cheilitis were the next commonly seen, each with an equal prevalence of 14.2 %.
Group 2 (Andolex-C® mouth rinse) showed a statistically significant improvement in
quality of life on all subscales related to functioning, pain, psychological and social
aspects when using the OHIP index. The patients demonstrated substantial reduction of
[64%] of mouth pain and/or discomfort and a 73% reduction of oral lesions compared to
Group 1 where there was a much smaller [22%] reduction of mouth pain and/or
discomfort and a 40% reduction of the oral lesions.
Conclusion: Andolex-C® mouth rinse improved the quality of life of HIV-infected
patients who presented with mouth pain and/or discomfort and demonstrated that in
combination with proper oral care and good hygiene habits, this regimen could be
recommended for oral palliation in HIV positive patients.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/5829 |
| Date | 04 November 2008 |
| Creators | Malele, Yolanda |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | application/pdf, application/pdf, application/pdf |
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