The inflammatory response due to chronic smoking in COPD patients has been well characterized with increases in CD3+ T lymphocytes. A murine model was chosen in our laboratory as a good model of human emphysema. / The first part of my project was to characterize the lung inflammatory response via immunocytochemistry in each mouse strain exposed to chronic smoke inhalation for a six-month period. / Several T lymphocyte subsets (i.e. naive, central memory and effector memory) have been characterized in the immune system both in humans and mice. These subsets have different homing potentials and effector functions, and can be identified with cell surface markers. The second part of my project was to determine these T-cell subset ratios in the lungs of each strain after chronic smoke exposure. / The third part of my project was to assess apoptosis in each strain after smoke exposure.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.82444 |
| Date | January 2004 |
| Creators | Turcotte, Antony |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Pathology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002199191, proquestno: AAIMR12559, Theses scanned by UMI/ProQuest. |
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