Nitric oxide (NO) and endothelin-1 (ET-1) are ubiquitous molecules whose actions have been implicated in several airway and vascular pathologies. NO is a free radical produced by the action of inducible and constitutive nitric oxide syntheses (NOS II and NOS III, respectively). NO possesses a wide range of actions including cellular damage which is mediated in part by peroxynitrite (ONOO-), an oxidant formed by the rapid reaction of NO with superoxide. ET-1 is a vasoconstrictor with well known mitogenic properties. In view of the physiologic properties of NO and ET-1, as well as the implication of these molecules in several pulmonary pathologies, we hypothesized that fibroproliferative lung disorders are associated with the cellular induction of NOS, ONOO-, and ET-1. Localization of these agents were qualitatively and quantitatively analyzed using immunohistochemistry and in situ hybridization in several proliferative lung disorders. / These findings are essential for our understanding of the pathogenesis of lung disease and the biology of vasoactive substances. They also suggest a possible role for both the NO and ET pathways in the functional and morphological abnormalities in proliferative disorders of the lung. (Abstract shortened by UMI.)
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.20586 |
| Date | January 1998 |
| Creators | McDermott, Colleen D. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Pathology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001605526, proquestno: MQ44219, Theses scanned by UMI/ProQuest. |
Page generated in 0.0014 seconds