The overall aims of my PhD research project were to identify which particular gamma-amino butyric acid A receptor (GABAAR) subunits are expressed by neurochemically defined cell-types of the enteric nervous system (ENS) of the mouse colon, and what effect the pharmacological activation of specific receptor subtypes had on colonic contractility, as well as assessing whether two key determinants of gastrointestinal (GI) plasticity, namely stress and ageing, altered such GABAAR expression and functional phenotypes in the colon.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:664855 |
| Date | January 2015 |
| Creators | Seifi, Mohsen |
| Contributors | Swinny, Jerome Dominic ; Brown, James Francis ; Mills, Jeremy James |
| Publisher | University of Portsmouth |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | https://researchportal.port.ac.uk/portal/en/theses/molecular-and-functional-characterisation-of-gabaa-receptors-in-the-enteric-nervous-system-of-the-mouse-colon(cbea652f-8986-4a07-92ba-ed44b17b8bea).html |
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