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Neural substrates of sublexical processing for spelling

We used fMRI to examine the neural substrates of sublexical phoneme-grapheme conversion during spelling in a group of healthy young adults. Participants performed a writing-to-dictation task involving irregular words (e.g., choir), plausible nonwords (e.g., kroid), and a control task of drawing familiar geometric shapes (e.g., squares). Written production of both irregular words and nonwords engaged a left hemisphere perisylvian network associated with reading/spelling and phonological processing skills. Effects of lexicality, manifested by increased activation during nonword relative to irregular word spelling, were noted in anterior perisylvian regions (posterior inferior frontal gyrus/operculum/precentral gyrus/insula), and in left ventral occipito-temporal cortex. In addition to enhanced neural responses within domain-specific components of the language network, the increased cognitive demands associated with spelling nonwords engaged domain-general frontoparietal cortical networks involved in selective attention and executive control. These results elucidate the neural substrates of sublexical processing during written language production and complement lesion-deficit correlation studies of phonological agraphia.

Identiferoai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/622997
Date01 1900
CreatorsDeMarco, Andrew T., Wilson, Stephen M., Rising, Kindle, Rapcsak, Steven Z., Beeson, Pélagie M.
ContributorsDepartment of Neurology, University of Arizona
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Source SetsUniversity of Arizona
LanguageEnglish
Detected LanguageEnglish
TypeArticle
Rights© 2016 Elsevier Inc. All rights reserved.
Relationhttp://linkinghub.elsevier.com/retrieve/pii/S0093934X16300487

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