Becauseo f the importance of phthalocyaninesa s functional materials and in medicine their synthesis and applications have been well documented in the literature. In the introductory chapter (chapter 1) a brief account of preparative methods and applications is outlined. Photodynamic therapy (PDT) is becoming a widely investigated area of research. Phthalocyanine drug candidates for PDT have received a great deal of interest. Novel aromatic, heteroaromatic and functionalised aromatic asymmetric 3: 1 phthalocyaninesw ere synthesisede, xploiting the Suzuki cross-coupling reaction. Systematic investigation into their possible use as PDT candidates was explored in chapter 2. As a result of unexpected interactions between pyridyl functionalised 3: 1 zinc phthalocyanines, further investigation into complexes of `edge-to-face' assembliesw as undertaken.T he synthesiso f these assembliesth rough Lewis acid/base interactions between the nitrogen lone pair and a metal centre has been investigatedb y 'H NMR spectroscopy.A pplication to both phthalocyaninea nd phthalonitrile compounds produced some interesting `supramolecular' assemblies. Finally, to further exploit these interactions a photoswitchable, selfassembledm onolayer wasp repared.T he monolayerw as designedt o isomerise under irradiation with light, to facilitate an `on-off type switch, that could bind a metal centred phthalocyanine.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:365014 |
| Date | January 2001 |
| Creators | Barthelemy, Dean |
| Publisher | University of East Anglia |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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