<p>Ispitana je direktna i indirektna fotoliza alprazolama (ALP) i amitriptilina (AMI)<br />primenom UV, vidljivog i simuliranog sunčevog zračenja (SSZ). Takođe, praćena je stabilnost vodenih rastvora ALP i AMI u mraku. U okviru ispitivanja fotokatalitičke razgradnje ALP,ispitana je efikasnost ZnO i TiO<sub>2 </sub>Degussa P25 primenom UV i SSZ. Takođe, proučavan je utica jmasene koncentracije fotokatalizatora, pH, kao i<br />uticaj hvatača radikala/šupljina i elektron-akceptora. Praćen je stepen mineralizacije<br />merenjem ukupnog organskog ugljenika i primenom jonske hromatografije. Takođe,<br />detaljno su ispitani reakcioni intermedijeri. Dalje,ispitano je ponovno korišćenje ZnO u tri uzastopna procesa razgradnje ALP. U cilju praćenja citotoksičnosti ALP, ispitan je in vitro rast dve ćelijske linije: Neuro-2a i MRC-5. Zatim,proučavana je efikasnost sintetisanih ZnO (ZnO modifikovani mlevenjem i kalcinacijom, ZnO dopirani jonima Mg(II), ternarni i mešani cink-kalaj-oksidi) i TiO<sub>2</sub> (anatas TiO<sub>2</sub> nedopirani i dopirani La(III)-jonima, brukitni TiO2) nanoprahova u razgradnji ALP primenom UV i SSZ. U okviru fotokatalitičke razgradnje AMI, ispitana je efikasnost razgradnje pri različitim eksperimentalnim uslovima (uticaj vrste fotokatalizatora i zračenja, masene koncentracije fotokatalizatora, početne koncentracije supstrata, uticaj prisustva kako hvatača radikala i šupljina, tako i elektron-akceptora). Praćen je stepen mineralizacije merenjem ukupnog organskog ugljenika i primenom jonske hromatografije. U cilju praćenja citotoksičnosti AMI, ispitan je in vitro rast četiri ćelijske linije: Neuro-2a, MRC-5, H-4-II-E i HT-29. Zatim, proučavana je efikasnost sintetisanih TiO<sub>2</sub>/polianilin nanokompozitnih prahova, kao i prevlaka čistog TiO<sub>2 </sub>i WO<sub>3</sub>/TiO<sub>2</sub> u razgradnji AMI primenom UV i SSZ. Takođe, ispitan je uticaj strukture supstrata na efikasnost fotokatalitičke razgradnje kroz ispitivanje efikasnosti sintetisanih TiO<sub>2</sub> nanoprahova dopiranih jonima W(VI), zatim mešanih cink-kalaj-oksid nanoprahova, kao i indijum-cink-oksid nanoprahova primenom UV i SSZ.</p> / <p>Direct and indirect photolysis of alprazolam (ALP) and amitriptyline (AMI) were studied using UV, visible, and simulated solar irradiation (SSI). Also, the stability of the ALP and AMI aqueous solutions in the dark were monitored. Photocatalytic degradation of ALP was studied in the presence of ZnO and TiO<sub>2</sub> Degussa P25 using UV and SSI. Also, the influence of the photocatalyst loading, pH, as well as the influence of the radical and holes scavengers and electron acceptors were studied. The degree of mineralization was monitored by measuring of total organic carbon and using ion chromatography. Also, reaction intermediates were examined in detail. Further, reusabillity of ZnO was investigated in three consecutive degradation processes of ALP. In order to get insight into the cytotoxicity of the ALP and intermediates formed during photocatalytic degradation, their influence on the growth of two cell lines: Neuro-2a and MRC-5 were investigated. Then, the efficacy of synthesized ZnO (ZnO modified with milling and calcination, ZnO doped with Mg(II) ions, ternary and coupled binary tin-zinc-oxide) and TiO<sub>2</sub> (anatase TiO<sub>2</sub> undoped and doped with La(III) ions and brookite TiO<sub>2</sub>) nanopowders in ALPdegradation using UV and SSI were investigated. Within the photocatalytic degradation of AMI, the degradation efficiency under different experimental conditions was studies (influence of the photocatalyst and irradiation type, photocatalyst loading, initial substrate concentration, the effect of the presence of radical and holes scavengers, and electron acceptors). The degree of mineralization was monitored by measuring of total organiccarbon and using ion chromatography. In order to study the cytotoxicity of AMI and degradation intermediates, their influence on the growth of four cell lines: Neuro-2a, MRC-5, H-4-II-E, and HT-29 were investigated. Then, the efficacy of synthesized TiO2/polyaniline nanocomposite powders, as well as photocatalysts of pure TiO<sub>2</sub> and WO<sub>3</sub>/TiO<sub>2</sub> in the form of films in AMI degradation using UV and SSI were studied. In addition, the effect of the substrate structure on the efficiency of photocatalytic degradation was studied by testing the activity of synthesized TiO<sub>2 </sub> nanopowders doped with W(VI) ions, then coupled binary tin-zinc- oxide nanopowders, as well as coupled binary indium-zinc- oxide nanopowders using UV and SSI.</p>
| Identifer | oai:union.ndltd.org:uns.ac.rs/oai:CRISUNS:(BISIS)107242 |
| Date | 06 July 2018 |
| Creators | Finčur Nina |
| Contributors | Abramović Biljana, Jovanović Ljiljana, Šojić Merkulov Daniela, Šćepanović Maja, Ivetić Tamara |
| Publisher | Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, University of Novi Sad, Faculty of Sciences at Novi Sad |
| Source Sets | University of Novi Sad |
| Language | Serbian |
| Detected Language | English |
| Type | PhD thesis |
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