Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Natália Pribylincová Consultant: Doc. RNDr. Milan Řehula, CSc. Effect of ascorbic acid on the parameters of compression equation Many mathematical models describing the compressing process are widely used in the development of new medicinal products in form of tablets. This process can be evaluated by means of compaction equations or throughout the viscoelastic properties. Compaction equation expresses dependency on height, volume or density of the used material which is being compressed by the applied compacting pressure. Based on the gained parameters, it is possible to describe specifically various stages of the compaction process, to determine characteristic properties of the studied material and accordingly to examine its mechanism. This thesis deals with the impact of the ascorbic acid on the parameters of compaction equation. The paperwork evaluates a mixture consisting of ascorbic acid (AA) and microcrystalline cellulose (MCC) in the ratio of MCC : AA 100:0, 75:25, 50:50, 25:75, 0:100. . The mostly used compression equations are described in the theoretic part. The three - exponential equation by Řehula created at the Department of Pharmaceutical Technology at Charles...
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:323784 |
| Date | January 2013 |
| Creators | Pribylincová, Natália |
| Contributors | Řehula, Milan, Ondrejček, Pavel |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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