Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Šárka Hávová Supervisor: PharmDr. Jitka Mužíková, Ph.D. Title of diploma thesis: A study of compaction process and properties of tablets with hypromellose and α-lactose monohydrate Thesis studied the co-processed dry binder RetaLac® from the aspect of his compressibility and dissolution of the active ingredient from tablets. RetaLac® contains α-lactose monohydrate and hypromellose in the identical proportion. The same parameters were tested in the corresponding physical mixtures of FlowLac® 100 with various types of hypromellose (Metolose® 100 SR, Metolose® 4000 SR, Metolose® 100 000 SR) and compared with the substance RetaLac® . Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets. Salicylic acid was used as the model active ingredient. Dissolution testing was performed using the method of the rotating basket.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:337309 |
| Date | January 2014 |
| Creators | Hávová, Šárka |
| Contributors | Mužíková, Jitka, Šnejdrová, Eva |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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