This study aims to introduce a systematic procedure for identifying potential novel drug-polymer combinations suitable for a magnetic field-assisted drug delivery system. Specific details of the design exploration exercise will be presented but the physics will only be addressed conceptually. This design process uses response surface design exploration used extensively in engineering fields that statistically predict optimal fluid, electrical, and mechanical designs. Although drug development is a very unique field, it is perhaps even better suited for the design exploration process than the fields that are currently using it. In this workflow, a variety of simulation tools work in tandem to predict the chemical makeup of a polymer that is effective at helping keep the drug stable and inert but also released from the drug when triggered so the cancer drug can be active. The workflow consists of a fixed set of initial input parameters that serve as the guides to this investigation. These inputs are fed into, a design of experiments table, a solver, and then output into a response surface. The response surfaces generated can then be used to alter the parameters of the test to further optimize the drug candidate list. At the end of this procedure, there will be a list of polymer candidates, for a variety of given drug types. Those drugs can then potentially be synthesized. Through this approach, the study aims to enhance the efficacy and specificity of magnetic field-assisted drug delivery systems, contributing to advancements in cancer treatment.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc2356150 |
| Date | 07 1900 |
| Creators | Jensen, Jesse Lee |
| Contributors | Buongiorno Nardelli, Marco, Weathers, Duncan, Perez, Jose |
| Publisher | University of North Texas |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | Text |
| Rights | Public, Jensen, Jesse Lee, Copyright, Copyright is held by the author, unless otherwise noted. All rights Reserved. |
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