Islands have been considered natural laboratories to study evolutionary processes. Ibiza is a small island in Spain whose population stands out from other Spanish populations due to its particular demographic and historical processes. War, famine, and several epidemics have af fected Ibizans, and these phenomena could have left signatures of positive selection in their genomes. Here, we used three different methodologies to detect positive selection: The Popu lation Branch Statistic (PBS), the Integrated Haplotype Score (iHS), and the Cross-Population Extended Haplotype Homozygosity (XP-EHH). We used a sliding windows approach to control for spurious results. The candidate windows for selection were chosen using three different criteria for each test: maximum and mean score within each window, and proportion of high scores in each window. Only the windows being simultaneously on the top of each of the three criteria were selected for annotation and enrichment analyses. The most common traits asso ciated with the SNPs present in the candidate windows were blood function, cardiovascular diseases, body mass measures, lipid metabolism, renal function, and skin diseases. We sug gest some hypotheses to explain the selection signatures related to some of these traits and some recommendations for further studies to overcome the present research's limitations.
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:uu-441567 |
| Date | January 2021 |
| Creators | Londono-Correa, Diego |
| Publisher | Uppsala universitet, Institutionen för biologisk grundutbildning, Uppsala universitet, Institutionen för organismbiologi, Institute of Evolutionary Biology, CSIC-UPF, Barcelona. |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Student thesis, info:eu-repo/semantics/bachelorThesis, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
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