<p><a>Preeclampsia leads to increased risk of
morbidity and mortality for both mother and fetus. Most previous studies have
largely neglected mechanical compression of the left renal vein by the gravid
uterus as a potential mechanism. In this study we first used a murine model to
investigate the pathophysiology of left renal vein constriction. The results
indicate that prolonged renal vein stenosis after 14 days can cause renal
necrosis and an increase in blood pressure (BP) of roughly 30 mmHg. The second
part of this study aimed to automate a diagnostic tool, known as the supine
pressor test (SPT), to enable pregnant women to assess their preeclampsia development
risk. A positive SPT has been previously defined as an increase of at least 20
mmHg in diastolic BP when switching between left lateral recumbent and supine
positions. The results from this study established a baseline BP increase
between the two body positions in non-pregnant female subjects and demonstrated
the feasibility and utility of an automated SPT in pregnant women. Our results
demonstrate that there is a baseline increase in BP of roughly 10-14 mmHg and
that pregnant women can autonomously perform the SPT. Overall, this work in
both rodents and humans suggests that 1) stenosis of the left renal vein in
mice leads to elevation in BP and acute renal failure, 2) non-pregnant women
experience a baseline increase in BP when they shift from left lateral recumbent
to supine position, and 3) the SPT can be automated and used autonomously.</a></p>
<br>
<p> </p>
| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/8011358 |
| Date | 15 May 2019 |
| Creators | Hamna Qureshi (6611528) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/Automation_of_the_Supine_Pressor_Test_for_Preeclampsia/8011358 |
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