Background: Little is known about long-term pediatric health outcomes following influenza vaccination during pregnancy.
Objectives: The objectives of this study were to assess the associations between prenatal exposure to maternal pandemic H1N1 (pH1N1) influenza vaccination and pH1N1 illness, with long-term immune-related pediatric health outcomes.
Methods: This retrospective cohort study used a province-wide birth registry from Ontario, individually linked with health administrative databases to ascertain study outcomes over five years of follow-up.
Results: We found a weak, but statistically significant, increased association between prenatal pH1N1 influenza vaccination and pediatric asthma, and an inverse association with gastrointestinal infections; otherwise, no other significant associations were observed. Conversely, significant increased associations were observed between pH1N1 influenza illness during pregnancy and all study outcomes.
Conclusions: The findings of this study support the safety of influenza vaccination during pregnancy; however more research in this area is required, particularly for seasonal influenza vaccine.
| Identifer | oai:union.ndltd.org:uottawa.ca/oai:ruor.uottawa.ca:10393/38659 |
| Date | 07 January 2019 |
| Creators | Walsh, Laura |
| Contributors | Fell, Deshayne, Hawken, Steven |
| Publisher | Université d'Ottawa / University of Ottawa |
| Source Sets | Université d’Ottawa |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | application/pdf |
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