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Previous issue date: 2013-11-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Preeclampsia is defined as an extremely serious complication of the pregnancy-puerperium cycle with delayed emergence of cardiovascular risk factors, including
metabolic syndrome. The research aimed estimate the prevalences of metabolic syndrome
and associated factors in women with preeclampsia and normal pregnancy followed five
years after childbirth. This is a cross-sectional observational study using a quantitative
approach, conducted at a maternity school in the city of Natal in Rio Grande do Norte
state. The sample was composed of 70 women with previous preeclampsia and 75 normal
selected by simple random probability sampling. Subjects were analyzed for
sociodemographic, obstetric, clinical, anthropometric and biochemical parameters.
International Diabetes Federation criteria were adopted to diagnose metabol ic syndrome.
The Kolmogorov-Smirnov, Mann-Whitney, Student s t, Pearson s chi-squared, and Fisher s
exact tests, in addition to simple logistic regression, were used for data analysis, at a 5%
significance level (p ≤ 0.05). Statistical tests demonstrated elevated body mass index (p =
0.001), predominance of family history of diabetes mellitus (p = 0.022) and significantly
higher prevalence of metabolic syndrome in the preeclampsia group (37.1%) when
compared to normal (22.7%) (p = 0.042). Intergroup comparison showed a high number of
metabolic syndrome components in women with previous preeclampsia. Altered systolic
and diastolic blood pressure (p < 0.001) was the most prevalent, followed by low
concentrations of high-density lipoproteins (p = 0.049), and hyperglycemia (p=0.030).
There was a predominance of the metabolic syndrome in women with schooling 0-9 years
(42.4%) (p = 0.005), body mass index above 30Kg.m
2
(52.3%) (p < 0.001), uric acid high
(62.5%) (p = 0.050 and family history of hypertension (38.5%) (p< 0.001).
Multivariate analysis of the data showed that the body mass index above 30 kg.m2,
education level less than 10 years of study (p < 0.001) and family history of hypertension
(p = 0.002) remained associated with the metabolic syndrome after multivariate analysis of
the data. It is considered Women with previous preeclampsia exhibited high prevalence of
metabolic syndrome and their individual components in relation to normal, especially,
altered systolic and diastolic blood pressure, low concentrations of high-density
lipoproteins and hyperglycemia. The factors associated to this ou tcome were obesity, less
than 10 years of schooling, and family history of hypertension. Overall, this study identified
young women with a history of PE exposed to a higher cardiovascular risk than normal / A pr?-ecl?mpsia ? uma complica??o de extrema gravidade do ciclo grav?dico puerperal e
contribui com o surgimento tardio de fatores de risco cardiovascular, dentre os quais a
s?ndrome metab?lica. A pesquisa objetivou estimar as preval?ncias da s?ndrome
metab?lica e fatores associados em mulheres que apresentaram pr?-ecl?mpsia e
gravidez normal, acompanhadas cinco anos ap?s o parto. Trata-se de um estudo
observacional transversal de abordagem quantitativa, realizado em uma maternidade
escola no munic?pio de Natal, Rio Grande do Norte. A amostra foi constitu?da por 70
mulheres com pr?-ecl?mpsia pr?via e 75 normais selecionadas por meio do m?todo de
amostragem probabil?stica aleat?ria simples, do banco de dados do grupo de pesquisa
Sa?de da Mulher do Departamento de Tocoginecologia da Universidade Federal do Rio
Grande do Norte, das quais foram analisados os par?metros sociodemogr?ficos,
obst?tricos, cl?nicos, antropom?tricos e bioqu?micos. Para diagn?stico da s?ndrome
metab?lica, adotou-se o crit?rio estabelecido pela International Diabetes Federation.
Quanto ? an?lise dos dados, foram aplicados testes estat?sticos de Kolmogorov-Smirnov,
Mann-Whitney, t de Student, Qui Quadrado de Pearson, exato de Fisher e modelo de
regress?o log?stica simples com n?vel de signific?ncia estat?stica de 5% (p≤ 0,05). Ap?s
aplica??o dos testes estat?sticos constatou-se um ?ndice de massa corp?rea elevado (p =
0,001), predom?nio de antecedentes familiares de diabetes mellitus (p = 0,022) e
preval?ncia significativamente maior da s?ndrome metab?lica no grupo com pr?-ecl?mpsia
(37,1%) em rela??o ?s normais (22,7%) (p = 0,042). Comparando os grupos, verificou-se
um n?mero elevado de componentes da s?ndrome metab?lica nas mulheres com pr?-ecl?mpsia pr?via. A press?o arterial sist?lica e diast?lica alteradas (p < 0, 001) foi o mais
prevalente, seguido da baixa concentra??o de lipoprote?nas de alta densidade (p = 0, 049)
hiperglicemia (p = 0,030). Houve o predom?nio da s?ndrome metab?lica nas mulheres com
escolaridade de 0 a 9 anos (42,4%) (p = 0,005), ?ndice de massa corp?rea acima de
30Kg.m
2
(52,3%) (p < 0,001), ?cido ?rico elevado (62,5%) (p = 0,050) e hist?rico familiar
de hipertens?o arterial (38,5%) (p < 0,001). A an?lise multivariada dos dados apontou
que o ?ndice de massa corp?rea acima de 30 kg.m
2
, grau de escolaridade menor que 10
anos de estudo (p < 0,001) e antecedentes familiares de hipertens?o arterial (p = 0,002)
permaneceram associados ? s?ndrome metab?lica. Considera-se que as mulheres com
PE pr?via apresentavam uma elevada preval?ncia da s?ndrome metab?lica e de seus
componentes individuais em rela??o ?s normais, em particular, a press?o arterial sist?lica
e diast?lica alteradas, os n?veis baixos da concentra??o de lipoprote?nas de alta
densidade e a hiperglicemia. Os fatores independentemente associados a esse desfecho
foram: obesidade, grau de escolaridade inferior a 10 anos e hist?rico familiar de
hipertens?o arterial. De forma geral, este estudo identificou mulheres jovens com hist?rico
de PE expostas a um risco cardiovascular mais elevado do que as normais
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/13334 |
| Date | 27 November 2013 |
| Creators | Andrade, Ana Cristina de Ara?jo |
| Contributors | CPF:70410798487, http://lattes.cnpq.br/7207146627442417, Silva, Antonia Oliveira, CPF:32199724468, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4788600J7, Costa, Iris do C?u Clara, CPF:14076152468, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4794938J9, Carvalho, Maria Goretti Freire de, CPF:05601592420, http://lattes.cnpq.br/8934375314306198, Souza, Nilba Lima de, CPF:42997186404, http://lattes.cnpq.br/3552543432083948, Ara?jo, Ana Cristina Pinheiro Fernandes de |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Ci?ncias da Sa?de, UFRN, BR, Ci?ncias da Sa?de |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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