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Language Mapping with Dense Array EEG Source Localization: Implications for Neurosurgical Planning

Current language mapping protocols for neurosurgical planning are invasive, expensive, and not suitable for all surgical candidates. We investigated the potential of dense array EEG to determine hemispheric dominance for language and localize current sources of semantic and lower level language functions in the brain using a semantic decision task, a phonological decision task, and an acoustic decision task. Source estimates of N400-window ERPs (N365, N480) and the Late Positive Complex (LPC) localized strongly to medial temporal regions. Overall source estimates revealed a slight left lateralized network, with more posterior engagement for the semantic condition and more anterior engagement for the phonological condition. Source localization of the resulting t-test wave from the semantic - phonological highlighted a stronger left lateralized pattern of activation encompassing more of the semantic network. As a first pass these results are promising, but need to be investigated on individual subject ERPs.

Identiferoai:union.ndltd.org:uoregon.edu/oai:scholarsbank.uoregon.edu:1794/12464
Date January 2012
CreatorsNelson, Joseph, Nelson, Joseph
ContributorsTucker, Don
PublisherUniversity of Oregon
Source SetsUniversity of Oregon
Languageen_US
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
RightsAll Rights Reserved.

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