In order to search for bioactive compounds, we have studied the chemical constituents from the organic extracts of five soft corals including Sinularia lochmodes, Sinularia nanolobata, Sinularia grandilobata, Sinularia depressa and Lobophytum crassum. This study had led to the isolation of eighteen natural compounds 1¡Ð18, including seven new compounds, lochmolins A ¡Ð G (1 ¡Ð 7) from S. lochmodes, a new compound nanolobatolide (8) featuring with a new carbon skeleton from S. nanolobata, two new compounds grandilobatin G (9) and sinugrandisterol E (10) from S. grandilobata, a new compound depressoloide A (11) and a known compound sarcophytol L (12) from S.depressa, and three new compounds crassumolides G¡ÐI (13¡Ð15) along with three known compounds durmolides B and C (16 and 17) and
sinularolide C (18) from L. crassum. The structures of compounds 1¡Ð18 were established by detailed spectral data analysis (IR, MS, 1D & 2D NMR) and by comparison with the spectral data of the related known compounds. The relative stereochemistries of compound 8 was further confirmed by X-ray single-crystal diffraction analysis.
Among them, compounds 13¡Ð15 and 16¡Ð17 were found to show significant activity against the accumulation of the pro-inflammatory iNOS and COX-2 proteins at 10 £gM.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0907110-113349 |
| Date | 07 September 2010 |
| Creators | Tseng, Yen-Ju |
| Contributors | Fang-Rong Chang, Yang-Chang Wu, Jyh-Horng Sheu, Ping-Jyun Sung, Yao-Haur Kuo |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0907110-113349 |
| Rights | not_available, Copyright information available at source archive |
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