Quality of life is a key issue in disabling conditions like stroke. Unfortunately, quality of life is often difficult to quantify in a comprehensive measure that can be used in cost analyses. Preference-based health status measures meet this challenge. A health outcome generated by a preference-based measure is assigned one single value that captures and weighs the various losses and gains on the different attributes or domains covered by the measure. Possible scores on a preference-based measure range from 0 (worst possible health state) to 1 (best possible health state). As there is no existing preference-based health status measure specific for stroke, this doctoral project aimed to develop one for use as an outcome in clinical and economic studies of stroke. / Several steps were required to develop the Preference-based Stroke Index (PBSI), a 10-item comprehensive measure of health status post-stroke. In order to ensure high content validity, major efforts were placed to select items that were known to be impacted by a stroke and had been identified by stroke survivors as important to their health-related quality of life (HRQoL). A pilot study among long-term stroke survivors indicated good discriminative ability of the PBSI. Scaling properties and preference-weights obtained from individuals with stroke and their caregivers were used to develop a temporary summative score. There is evidence of convergent validity of the PBSI with the SF-36. Construct validation of the PBSI showed that the PBSI was able to differentiate HRQoL of individuals with stroke according to their level of functional independence and to their stroke severity at onset. / The development of a multiattribute utility function will need to be undertaken in the near future for further refinement of the PBSI.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.38511 |
| Date | January 2002 |
| Creators | Poissant, Lise |
| Contributors | Mayo, Nancy E. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (School of Physical and Occupational Therapy.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001941291, proquestno: NQ85733, Theses scanned by UMI/ProQuest. |
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