The renin angiotensin system (RAS), a homeostatic system involved in blood pressure and volume control, is implicated in the pathology of several risk factors for ischaemic stroke. Mounting evidence now suggests that the RAS may play a role in the pathophysiology of ischaemic stroke. This is thought to be due to an imbalance between the classical RAS axis, Angiotensin converting enzyme/Angiotensin II/Angiotensin II receptor type I (ACE/Ang II/AT1R), and the counter-regulatory RAS axis, Angiotensin converting enzyme 2/Angiotensin-(1-7)/Mas receptor [ACE2/Ang-(1-7)/MasR]. The counter- regulatory axis has been shown to provide neuroprotection in ischaemic stroke animal models. Therefore, the studies conducted in this thesis aimed to test the neuroprotective potential of Ang-(1-7) as a post-stroke therapy following transient focal cerebral ischaemia. Furthermore, experiments were conducted to test a potential synergistic effect between MasR and alternative Ang II receptor, Angiotensin II receptor type II (AT2R), agonism following stroke.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:744115 |
| Date | January 2018 |
| Creators | Arroja, Mariana Moreira |
| Publisher | University of Glasgow |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://theses.gla.ac.uk/9010/ |
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