Coronary arteries obstructed by atherosclerosis can be cleared by a balloon angioplasty accompanied by a permanent scaffolding implant ("stent"). There is, however, a 25--45% occurrence rate of excessive thickening of the treated vessel wall a few weeks post-angioplasty, leading to a re-obstruction of the vessel ("restenosis"), and recurrent symptoms. Endovascular radiotherapy, a potential preventive treatment against restenosis, can be delivered by a stent impregnated with radionuclides. The present thesis examines the local dosimetry of radioactive stents. A computer algorithm, D OSECOP, was developed based on the dose point kernel theory, to calculate the dose distribution created by a 32P-implanted stent in the surrounding vessel wall. The dosimetric significance of four parameters is also assessed, namely: (1) mechanical distortions of the stent, (2) the exact location of radionuclides on the stent, (3) the self-attenuation of the stainless steel stent, and (4) the width of the stent's struts in the calculation models.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.29958 |
| Date | January 1999 |
| Creators | Corbett, Jean-Francois. |
| Contributors | Corns, Robert A. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Medical Radiation Physics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001804641, proquestno: MQ70541, Theses scanned by UMI/ProQuest. |
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