This thesis presents two techniques for enhancing the volume coverage and temporal resolution of functional magnetic resonance brain imaging on conventional clinical scanners, namely, echo-shifting and retrospective temporal resolution selection (RTRS). The techniques are compared with conventional 2D gradient echo imaging on the bases of speed and sensitivity to functional changes, and the necessary theory is reviewed to develop physical models explaining the different properties observed. / Acquisition, reconstruction, and analysis software packages for functional brain mapping are presented and demonstrated with visual stimulation. The echo-shifted sequence permitted acquisition of 3D maps of brain activity which could be better correlated with local anatomy than 2D maps, and the RTRS method provided physiological response curves with greatly increased temporal resolution.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.23895 |
| Date | January 1995 |
| Creators | Hoge, Richard D. |
| Contributors | Pike, G. B. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Medical Radiation Physics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001481370, proquestno: MM12204, Theses scanned by UMI/ProQuest. |
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