Propofol is a widely in use anesthetic drug. Propofol’s abuse liability has been supported by many case reports and a few animal studies. However, propofol’s reinforcing properties have not yet been investigated in-depth. In this study, multiple aspects of propofol’s abuse-related behaviour were investigated using the drug self-administration model in rats. METHODS: Rats were subjected to propofol self-administration under a fixed ratio 1 (FR1) schedule and different aspects of propofol self-administration behaviour including acquisition, maintenance of the behaviour under a higher ratio schedule, extinction and reinstatement were investigated. RESULTS: Rats acquired propofol self-administration under a FR1 schedule. The acquired behaviour was maintained under a FR2 schedule, showed a modest variation over a range of doses, and was extinguished upon substitution of vehicle for propofol, showing no reinstatement using a range of priming doses of propofol. CONCLUSION: Propofol has abuse potential showing modest reinforcing properties under our experimental conditions.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/42677 |
| Date | 21 November 2013 |
| Creators | Baghai Wadji, Fariba |
| Contributors | Tyndale, Rachel |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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