The acute phase response induced by bacterial pyrogens, but not by viral pyrogens,
has been thoroughly investigated. Polyinosinic:polycytidylic acid (poly I:C) is a
synthetic viral pyrogen that is used to simulate viral infection. This dissertation
describes how I determined an effective peripheral route and dose of administration
of poly I:C to rats. Thereafter I investigated whether poly I:C induced sickness
behaviour, and whether repeated administration of poly I:C resulted in the
development of tolerance. Intraperitoneal administration of at least 1000μg/kg poly
I:C induced fevers in rats, but not sickness behaviour. Unlike repeated administration
of LPS, repeated administration of poly I:C in rats did not result in the development
of tolerance.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/5796 |
| Date | 23 October 2008 |
| Creators | Fajandar, Shaheen |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | application/pdf |
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