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Regiospecifické deriváty cyklamu pro radiomedicinské a MRI aplikace / Regiospecific cyclam derivatives for radiomedical and MRI utilizations

Cyclam (1,4,8,11-tetraazacyclotetradecane) derivatives are widely used for various purposes. In a medicine they are applied as ligands for radiometals applied as diagnostic or therapeutic agents against tumours, hypoxic brain tissues etc. In this thesis a new method for asymmetric cyclam derivati- ves preparation was developed. New cyclam derivatives with trifluoroethyl groups were prepared too. Paramagnetic metal complexes with these fluori- nated ligands can be used as contrast agents for 19 F-MRI. Keywords: Cyclam; Non-symmetric protection; Contrast agents; Trifluoroethylamines; Paramagnetic relaxation; 19 F-MRI.

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:321916
Date January 2013
CreatorsBlahut, Jan
ContributorsKotek, Jan, Drahoňovský, Dušan
Source SetsCzech ETDs
LanguageCzech
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/masterThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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