A thesis submitted to the Faculty of Engineering and the Built
Environment, University of the Witwatersrand, Johannesburg, in
fulfilment of the requirements for the degree of Doctor of Philosophy.
Johannesburg, 2016 / The theoretical and experimental investigation of electron spin-resonance relaxation to
deposit thermal energy into liquid gadolinium-based contrast agents for cancer hyperthermia
treatment is presented. Previous works suggest that using protons in water are
inadequate, with a thermal deposition rate of approximately 1 ◦C per two years. A novel
component of this research relies on the use of gadolinium-chelated molecules, which are
currently used as contrast agents in clinical MRI scans. The chelating agents, or ligands,
investigated are Gadobenate (MultiHance R
), Gadopentetate (Magnevist R
), Gadoterate
(DotaremR
) and Gadoteridol (ProHance R
). The gadolinium atom has seven unpaired
electrons in its inner f shell orbital and as a result has a 660 times stronger paramagnetic
response when placed in an external magnetic field. The research tests the hypothesis
that by using an appropriate external homogeneous DC magnetic field, together with a radiofrequency
excited resonator, that a measurable amount of thermal energy is deposited
into a liquid gadolinium-based contrast agent. The aim of this research is to ultimately
discover a new cancer hyperthermia treatment. The research theory suggests that a temperature
rate of 13.4 ◦C · s−1 can be achieved using the gadolinium-based contrast agents
under certain experimental conditions, and a maximum of 29.4 ◦C · s−1 under more optimal
conditions. The temperature rates are calculated using parameter values commonly
found in literature and practice. The simulation and design of the DC magnetic field coil
system is discussed, together with the simulation results and design parameters of the radiofrequency
loop-gap resonator. The experimental results and analysis indicate that the
selected contrast agents have varied responses based on their chemical nature and that
only two out of the four contrast agents, Dotarem and ProHance, show a measurable
effect albeit sufficiently small that statistical techniques were necessary to distinguish
the effect from background. A model fit to the data is performed in order to determine
the spin-lattice relaxation time of the contrast agents under the specified experimental
conditions. The model estimate is significantly smaller than the values found in literature
under similar conditions, with a spin-lattice relaxation time τ1e of approximately 0.2 ps
compared to the literature value of 0.1 ns. Although the observed electron spin resonance
heating rate is in the milli-Watt range it is still notably larger (167 000 times) compared
to the heating rate obtained using protons. The low temperature rates suggest that a
more suitable agent or molecule with a larger spin-relaxation time be used, in order to
achieve clinical useful temperature rates in the range of 14 ◦C · s−1. / MT2017
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/22675 |
| Date | January 2016 |
| Creators | Dinger, Steven Conrad |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | Online resource (103 leaves), application/pdf, application/pdf |
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