ABSTRACT
This study was designed to screen antiretroviral therapy (ART)-naïve human immunodeficiency
virus (HIV) infected patients for proteinuria, using urine dipsticks, at the HIV outpatient clinic at
Johannesburg Hospital in an attempt to detect and treat early renal disease. In those with
persistent proteinuria, a marker of kidney disease, renal biopsy was performed, ART with and
without angiotensin-converting enzyme inhibitors (ACE-I) was initiated and patients were
followed up for immunological and renal responses. After a minimum period of 12 months, a
repeat biopsy was performed, where possible, to determine whether the histological lesions had
responded to treatment. During urinary screening, proteinuria, leucocyturia and microscopic
haematuria were common. Sterile leucocyturia may be associated with co-morbid sexually
transmitted infection or tuberculosis. In the group that underwent renal biopsy with treatment,
the renal and immunological response, before and after ART was highly statistically significant.
Renal and immunological responses to ART were assessed by reduction in proteinuria with
increased GFR, increased CD4 count with reduction in HIV viral load, respectively. On biopsy,
HIV-associated immune complex disease was more common than HIVAN, a finding that
contradicts international and some local data. Resolution of proteinuria was relatively rapid in
comparison to the histological response to treatment, an effect not previously shown. This is the
first study of its kind, to the author’s knowledge, that prospectively evaluates the effect of ART
with/ ACE-I in ART-naïve HIV infected patients with both clinicopathological and histological
criteria. It has shown unequivocally, that renal disease, particularly if detected and treated early
in HIV infection, is responsive to treatment. These findings suggest screening for early detection
and treatment of HIV-associated renal disease should be mandatory in HIV clinics in South
Africa.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/6938 |
| Date | 08 May 2009 |
| Creators | Fabian, June |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf |
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