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Studies on Poly(ADP-ribose) Metabolism and Chromatin Structure

In these studies, a procedure which allowed the in vivo labeling and detection of poly(ADP-ribose) was combined with nuclear fractionation techniques to analyze the nuclear distribution of ADP-ribose polymers. The results from these studies suggest the occurrence of poly(ADP-ribose) metabolism in two compartments of chromatin; one that is nuclear matrix-associated and one that is not. The biological significance of this compartmentalization is conceptualization in a model. This model postulates that, under some physiological conditions, poly(ADP-ribose) metabolism accomplishes the reversible targeting of specific regions of chromatin to the nuclear matrix domain by modulating DNA-protein and or protein-protein interactions.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc798380
Date08 1900
CreatorsCárdenas-Corona, María E. (María Elena)
ContributorsJacobson, Myron, Benjamin, Robert C., Pirtle, Robert M., Harris, Ben G., Wimbish, Gary Harold, Wu, Edward
PublisherUniversity of North Texas
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatxi, 163 leaves : ill., Text
RightsPublic, Cárdenas-Corona, María E. (María Elena), Copyright, Copyright is held by the author, unless otherwise noted. All rights

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