The role of tick saliva and tick salivary cystatins in the transmission of \kur{Borrelia burgdorferi} and the cystatin effect on experimental asthma in mice. / The role of tick saliva and tick salivary cystatins in the transmission of \kur{Borrelia burgdorferi} and the cystatin effect on experimental asthma in mice.

Description

The thesis focuses on the investigation of the role of tick salivary components in the course of Lyme disease in mice. It includes studies on the saliva-facilitated transmission of Borrelia burgdorferi in vivo and the effect of tick cysteine protease inhibitors (cystatins) both on murine immune cells and the transmission of B. burgdorferi spirochetes in mice. The thesis also reveals practical applications of salivary cystatins for the development of anti-tick vaccine and the application of the pharmacological action of a tick salivary cystatin for the therapy of the disease symptoms in a mouse model of experimental asthma.

Links & Downloads

1. http://www.nusl.cz/ntk/nusl-54771

Tags

Additional Fields

Identifer	oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:54771
Date	January 2011
Creators	HORKÁ, Helena
Source Sets	Czech ETDs
Language	Czech
Detected Language	English
Type	info:eu-repo/semantics/doctoralThesis
Rights	info:eu-repo/semantics/restrictedAccess