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Synthesis of (±)-methyl rocaglate using an unprecedented acetyl bromide mediated Nazarov reaction

To date, the Nazarov cyclization of a pentadienone has not been a proven methodology towards the construction of the core of the rocaglate natural products. It has been found that this conversion can be achieved using acetylbromide in excellent yield. This represents the first time acetylbromide has been employed in this manner. This methadology provides a very effective and direct route to the core structures of this class of molecules. / text

Identiferoai:union.ndltd.org:UTEXAS/oai:repositories.lib.utexas.edu:2152/ETD-UT-2012-05-5777
Date19 July 2012
CreatorsMoorhead, Eric J.
Source SetsUniversity of Texas
LanguageEnglish
Detected LanguageEnglish
Typethesis
Formatapplication/pdf

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