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HMG-CoA reductase inhibitors do not attenuate the inflammatory response associated with glutaraldehyde-fixed bioprosthetic heart valve conduits

Evidence suggests that there is an immunological response of the recipient to xenograft bioprosthetic heart valves. Information on the impact of HMG-CoA reductase inhibitors (statins) and their anti-inflammatory properties on bioprosthetic valve failure remains limited. We sought to examine the efficacy of statin therapy in a rodent model of bioprosthetic valve implantation.

To mimic the human scenario, fresh or glutaraldehyde-fixed aortic valve root conduits from Lewis rats or Hartley guinea pigs were microsurgically implanted intravascularly into the infra-renal aorta of Lewis rats. The syngeneic control group consisted of a fresh rat valve conduit implanted into a rat. The xenogeneic control group consisted of a glutaraldehyde-fixed guinea pig valve conduit implanted into a rat. Treatment groups consisted of xenogeneic groups treated with either daily steroids or statins.

Overall, steroid treatment attenuated the inflammatory response observed within the xenogeneic glutaraldehyde-fixed valve conduits. Treatment with statins did not decrease this inflammatory response.

Identiferoai:union.ndltd.org:MANITOBA/oai:mspace.lib.umanitoba.ca:1993/14909
Date17 January 2013
CreatorsKumar, Kanwal K.
ContributorsArora, Rakesh C. (Surgery) Jassal, Davinder S. (Physiology), Kardami, Elissavet (Human Anatomy & Cell Science) Freed, Darren H. (Surgery)
Source SetsUniversity of Manitoba Canada
Detected LanguageEnglish

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