Taurine transport in purified brush-border membranes from rodent kidney is concentrative and driven by the Na('+) gradient and transmembrane potential difference. The high-affinity, low-capacity carrier is specific for (beta)-amino compounds. / Inherited, strain-dependent influences on taurine reabsorption were investigated in the C3H/HeJ strain, a low excretor of taurine in urine and the C57Bl/6J strain, a high excretor. Although both strains transport taurine similarly at the luminal membrane, impaired exit at the baso-lateral membrane of renal epithelium in the hypertaurinuric strain results in increased intracellular levels of taurine and subsequent backflux into the urine. / The kidney is an important arbiter of taurine homeostasis. When animals are deprived of taurine, the kidney adapts by increasing taurine uptake at the renal brush-border membrane and in renal cortex slices; fractional excretion drops sharply. A change in plasma taurine may be the critical signal for adaptation.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.68583 |
| Date | January 1981 |
| Creators | Rozen-Palefsky, Rima. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Biology) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000127669, proquestno: AAINK52108, Theses scanned by UMI/ProQuest. |
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