Functionalized cyanophosphates are important starting materials for the synthesis of
beta-lactam ring moiety of beta-lactam antibiotics. The cyanophosphates are
synthesized starting from easily available acylphosphonate and ethylcyanoformate.
Acylphosphonates are synthesized starting from acylchloride and trimethylphosphite.
Addition of acylphoshonate to ethylcyanoformate furnishes the cyanophosphate with
the quaternary center.
| Identifer | oai:union.ndltd.org:METU/oai:etd.lib.metu.edu.tr:http://etd.lib.metu.edu.tr/upload/2/12609090/index.pdf |
| Date | 01 December 2007 |
| Creators | Reis, Barbaros |
| Contributors | Demir, Ayhan S |
| Publisher | METU |
| Source Sets | Middle East Technical Univ. |
| Language | English |
| Detected Language | English |
| Type | M.S. Thesis |
| Format | text/pdf |
| Rights | To liberate the content for METU campus |
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