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Previous issue date: 2003 / O ferro e nutriente essencial para todas as celulas humanas. Doadores de sangue perdem em cada doacao uma media de 242 t 17 mg de ferro e, em geral, os estoques de ferro sao pressionados pelas doacoes de repeticao a partir da 2a doacao de sangue por ano. Sabendo da importancia do ferro nas diversas celulas do nosso organismo, tivemos por objetivo avaliar se doadores de sangue do Hemocentro de Manaus (HEMOAM) desenvolvem sideropenia sem anemia apos doacoes consecutivas. Para isso, a ferritina serica foi medida em 528 doadores de sangue, do sexo masculino, com idade entre 18 a 61 anos, divididos em 313 doadores de repeticao, com 4 ou mais doacoes anuais, com intervalo entre elas de 8 a 10 semanas, e 215 primodoadores que compareceram ao hemocentro do Amazonas no periodo de setembro de 2001 a junho de 2002. Esses doadores foram classificados, conforme o numero de doacoes, em primodoadores (grupo 1), e doadores de repeticao, com 4 doacoes (grupo 2), com 5-9 doacoes (grupo 3), com 9-12 doacoes (grupo 4), e com mais de 12 doacoes (grupo 5). Utilizamos a determinacao da Ferritina serica pela tecnica de microparticula enzimaimunoensaio(MEIA), utilizando equipamento automatizado (Abott AXSYM system) e dos indices hermatimetricos em modelo ADVIATM 120. Deplecao do deposito de ferro, definida por niveis de ferritina menores de 20ng/l, foi encontrada em 7,4 por cento[16/215] dos primodoadores e em 48,6 por cento [152/313] dos doadores de repeticao. [p<0,001]a(au) / Iron is an essential nutrient for all human cells. Each donation spoils 24717mg of iron from the donor. Iron store are pressed by repeated donations, usually starting from the second donation in one year.
Serum levels of ferritin has been measured in 528 male blood donors, 18 to 61 years old, 313 of them with 4 or more donations in one year with intervals of 8 to 10 weeks, and 215 of them being first time donors. They attended the “Hemocentro do Amazonas”, from september 2001 to june 2002.
These donors were stratified by the number of donations, as first time donors (group 1), donors with 4 donations (group 2), 5 to 9 donations (group 3), 10 to 12 donations (group 4) and more than 12 donations (group 5).
Shortage of iron stores defined by serum ferritin values below 20ng/L was found in 7,4% (16/215) of first time donors, and in 48,6%(152/313) of multi-time donors. With more stringent criteria – ferritin values below 12ng/L - 3,7%(8/215) of first-time donors, as opposed to 24,9%(78/313) of multi-time donors, showed severe depletions.
It was clearly demonstrated that, within multi-time donors, depletions of iron stores were already present at the fourth donation, but with the greatest impact between the fifth and the nineth donation.
The influence of demographic, physiologic, social and economic factors was assessed. Family income, having a job, and the use of non-steroidal-anti-inflamatory drugs appeared as the most important co-variables for iron shortage in the population under study. Notwithstanding, there was a poor correlation between early stages of iron depletion and hematimetric indexes.
We concluded that multi-time donors, with more than 5 donations per year, should be monitored for iron depletion with the measurement of ferritin levels. It is important to create protocols to supply these donors at risk with iron reposition, with the aim of avoiding damage to their health, and consequent loss in quality and quantity in the collected blood. / BV UNIFESP: Teses e dissertações
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.unifesp.br:11600/19896 |
| Date | January 2003 |
| Creators | Passos, Leny Nascimento da Motta [UNIFESP] |
| Contributors | Universidade Federal de São Paulo (UNIFESP), Figueiredo, Maria Stella [UNIFESP] |
| Publisher | Universidade Federal de São Paulo (UNIFESP) |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | 102 p. |
| Source | reponame:Repositório Institucional da UNIFESP, instname:Universidade Federal de São Paulo, instacron:UNIFESP |
| Rights | info:eu-repo/semantics/openAccess |
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