Abstract
24£i-methylcholestane-3£],5£\,6£],25-tetrol-25-monoacetate (1), 24£i-methyl
cholestane-3£],5£\,6£],25-tetrol (2), 24£i-methylcholestane-1£],3£],5£\,6£],25-pentol
-25-monoacetate (3), (20S)-21-decanoxyl-24£i-methylcholestane-3£],5£\,6£],24 -tetrol (4), (20S)-21,24-diacetaoxy-24£i-methylcholestane-3£],5£\,6£]-triol (5) were isolated from the soft coral Sarcopyton glaucum which were collected from the Green island. The structures of 1~5 were established by spectroscopic data , compound 1~3 have been reported previously, compound 4 and 5 are new metabolites.
The cytotoxicity of compounds 1~5 against A-549, HT-29 and P388 cancer
cell lines was studied. Only compound 1 showed significant cytotoxicity against
the growth of HT-29 cells line. Compound 2~5 were found to be inactive against
the above three cancer cells lines.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0807101-171345 |
| Date | 07 August 2001 |
| Creators | Chen, Chien-Ting |
| Contributors | Jhy-Horng Sheu, Wei-Hsien Wang, Ian-Lih Psai |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0807101-171345 |
| Rights | off_campus_withheld, Copyright information available at source archive |
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