All animals exist in lifelong relations with a complement of bacteria. Because of the ubiquity of these symbioses as well as the derived biomedical applications, the study of both beneficial and pathogenic host-microbe associations has long been established. The monospecific light organ association between the Hawaiian sepiolid squid Euprymnascolopes and the marine luminous bacterium Vibrio fischeri has been used as a experimental model for the study of the most common type of animal-bacterial interaction, i.e., the association of coevolved Gram-negative bacteria with the extracellular apical surfaces of polarized epithelia. A fundamental step for understanding the mechanisms of host-symbiont associations lies in defining the genetic components involved; specifically defining changes in host gene expression. The studies presented in this dissertation identify and characterize V. fischeri-induced changes in host gene expression at both the transcript and protein level.
| Identifer | oai:union.ndltd.org:UHAWAII/oai:scholarspace.manoa.hawaii.edu:10125/1259 |
| Date | 12 1900 |
| Creators | Kimbell, Jennifer Loraine |
| Contributors | McFall-Ngai, Margaret |
| Publisher | University of Hawaii at Manoa |
| Source Sets | University of Hawaii at Manoa Libraries |
| Language | en-US |
| Detected Language | English |
| Type | Thesis, Text |
| Rights | All UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner., https://scholarspace.manoa.hawaii.edu/handle/10125/865 |
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