<p>The overall time and cost for a drug to go from the drug discovery to the consumer market is significant, showing a need for improved drug testing and discovery methods. Work on nonlinear optical methods for both small active pharmaceutical ingredient drug formulation analysis and large biological therapeutic stability testing has been shown to improve testing times for formulation, stability and dissolution testing. Herein, we review the existing and conventional approaches to address stability testing that the pharmaceutical industry uses, and how leveraging nonlinear optical (NLO) methods can improve the current challenges. The specificity, sensitivity and low limit of detection of second harmonic generation is discussed in application to crystal formation in small-molecule active pharmaceutical ingredients. The nonlinear optical methods second harmonic generation and two-photon excited ultraviolet fluorescence are directly compared to ‘gold standard’ powder X-ray diffraction, which is commonly used for measuring crystal formation and growth of active pharmaceutical ingredients in amorphous solid dispersions. In addition, the existing FRAP method (with multiple limitations) is improved upon with the ability to perform recovered diffusion coefficient data analysis in the spatial Fourier domain. The collective results discussed in this thesis are just a small subset of the total breadth of investigations marrying the new challenges in the pharmaceutical industry with the new NLO tools tailored to meet them</p>
| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/20359668 |
| Date | 28 July 2022 |
| Creators | Nita Takanti (9234683) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/thesis/NONLINEAR_OPTICAL_METHODS_AS_APPLIED_TO_LARGE_AND_SMALL_PHARMACEUTICAL_MODALITIES/20359668 |
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