Indiana University-Purdue University Indianapolis (IUPUI) / Habit expression is emerging as a theory of addiction: subjects begin to use drugs to attain positive reinforcing effects but continue to use in spite of negative effects because the behavior becomes habitual, and therefore divorced from its outcome. Many studies have shown that a history of drug and alcohol use lead to expedited acquisition of a habit, but the acute effects of these drugs on behavior is still unknown. Behaviors that result from acute intoxication, such as increased aggression, risky sexual behavior, and impaired judgment, could be interpreted as habitual: actions performed without regard for the outcome. Therefore, we studied the transition from goal-directed to habitual behavior, when a response is made regardless of outcome value, and how acute intoxication of ethanol (EtOH), amphetamine (AMP), nicotine (NIC), and yohimbine (YOH) affect the resulting behavior. Through a series of four experiments, selectively bred crossed High Alcohol Preferring (cHAP) mice were trained on an operant task to self-administer 1% banana solution, which was subsequently devalued via LiCl CTA. EtOH (1 & 1.5 g/kg), AMP (2.0 mg/kg), NIC (0.5 mg/kg), YOH (1.0 mg/kg), or SAL were administered prior to baseline and post-devaluation tests. We found that acute EtOH at 1- and 1.5-g/kg doses facilitated the expression of a habit, whereas all other pretreatments resulted in devaluation. These data may indicate a unique role for EtOH in facilitating the retrieval of habitual over outcome-based associations. This could shed light on why intoxicated individuals display impaired judgment and a mechanism by which relapse after a period of abstinence can occur.
| Identifer | oai:union.ndltd.org:IUPUI/oai:scholarworks.iupui.edu:1805/11052 |
| Date | 17 August 2016 |
| Creators | Houck, Christa A. |
| Contributors | Grahame, Nicholas J., Czachowski, Cristine Lynn, Goodlett, Charles R. |
| Source Sets | Indiana University-Purdue University Indianapolis |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
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