Photodynamic therapy (PDT) is a noninvasive method of treating malignant
tumors and age-related macular degeneration. Current practice of PDT is limited to a
few functionalized porphyrins, however these compounds are not considered to be
ideal drugs for use in PDT. Among the limitations, the most prominent is the low
extinction coefficient of porphyrins in the body& / #8217 / s therapeutic window. Therefore,
there is a significant impetus to develop novel and better efficiency sensitizers for
use in PDT.
Boradiazaindacenes (BODIPY dyes or difluoroboradipyrrines) are well known
fluorescent dyes. We discovered novel distyryl-derivatized boradiazaindacene dyes.
These dyes have strong absorptions beyond 650nm. In order to transform these novel
dyes into potential PDT reagents, bromine substituents were placed and then heavy
atom effect was showed. We also demonstrated that on red-light excitation, singlet
oxygen trap 1,3-diphenyl-iso-benzofuran is rapidly degraded.
| Identifer | oai:union.ndltd.org:METU/oai:etd.lib.metu.edu.tr:http://etd.lib.metu.edu.tr/upload/2/12607377/index.pdf |
| Date | 01 July 2006 |
| Creators | Dost, Zeynep |
| Contributors | Akkaya, Engin Umut |
| Publisher | METU |
| Source Sets | Middle East Technical Univ. |
| Language | English |
| Detected Language | English |
| Type | M.S. Thesis |
| Format | text/pdf |
| Rights | To liberate the content for METU campus |
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