It is a striking observation that tissue of patients invaded by the deep mycoses often lacks evidence of an inflammatory response. This lack of host response is often attributed to neutropenia secondary to chemotherapy. However, systematic studies do not support this simplistic explanation. However, invasive fungal lesions are characterized by abundant fungal functional amyloid, which in turn is bound by serum amyloid P component (SAP). We postulate that SAP is important in the local immune response in invasive fungal infections. The interaction between fungal functional amyloid, SAP, and the immune response in deep mycoses is discussed.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/622357 |
| Date | 05 1900 |
| Creators | Klotz, Stephen A., Sobonya, Richard E., Lipke, Peter N., Garcia-Sherman, Melissa C. |
| Contributors | Univ Arizona, Div Infect Dis, Univ Arizona, Dept Pathol |
| Publisher | OXFORD UNIV PRESS INC |
| Source Sets | University of Arizona |
| Language | English |
| Detected Language | English |
| Type | Article |
| Rights | © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Relation | https://academic.oup.com/ofid/article-lookup/doi/10.1093/ofid/ofw166 |
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