Two major aspects of CCK-induced satiety were examined in the
food deprived sham-feeding rat: the kinetics of the inhibition of
feeding produced by CCK and the interaction of CCK-induced satiety with
oropharyngeal stimulation. Four results were presented regarding the
kinetics of the CCK satiety effect. First, CCk administered coincident
with the initiation of sham feeding inhibits feeding in a dose-related
manner. Second, the increased efficacy of the higher dose of CCK
delivered at the same time as sham feeding results from an increase in
the size of maximum suppression and an increase in the time of
suppression effected via a decreased latency to suppression. Third, CCk
delivered 15 minutes before sham feeding begins has no effect on
feeding. Fourth, the administration of a long-lasting derivative of CCK
15 minutes prior to the initiation of sham feeding can suppress intake.
Two results were presented regarding the role of oropharyngeal
stimulation in CCK-induced satiety. First, it was shown that
oropharyngeal stimulation enhances the satiety action of CCK. Second,
the amount and pattern of feeding inhibition produced by CCK are
equivalent regardless of whether the peptide is administered coincident
with, or some time after, the initiation of sham feeding. The
implications of these results for the therapeutic use of this peptide
and its role in producing satiety are discussed. / Thesis / Master of Arts (MA)
| Identifer | oai:union.ndltd.org:mcmaster.ca/oai:macsphere.mcmaster.ca:11375/22769 |
| Date | 07 1900 |
| Creators | Forsyth, Peter Alexander |
| Contributors | Weingarten, H.P, Psychology |
| Source Sets | McMaster University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
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