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The inhibitory effect of sinefungin on juvenile hormone biosynthesis and development in locusts

The antibiotic fungal metabolite sinefungin is a potent inhibitor of S-adenosylmethionine-acceptor methyltransferases. Its effect on insect metabolism and especially on corpora allata farnesoic acid methyltransferase, which catalyzes the penultimate step of juvenile hormone biosynthesis, was investigated in Locusta migratoria. Injection of sinefungin results in a delay of imaginal molt and in suppression of ovary development. Isolated corpora allata are unable to synthesize juvenile hormone III in the presence of more than 1.0 mM sinefungin. In a cell-free system containing the S-adenosylmethionine-dependent farnesoic acid methyltransferase from corpora allata sinefungin is a competitive inhibitor of the synthesis of methylfarnesoate with Ki of 1 μM.

Identiferoai:union.ndltd.org:Potsdam/oai:kobv.de-opus-ubp:1681
Date January 1987
CreatorsFerenz, Hans-Jörg, Peter, Martin G.
PublisherUniversität Potsdam, Mathematisch-Naturwissenschaftliche Fakultät. Institut für Chemie
Source SetsPotsdam University
LanguageEnglish
Detected LanguageEnglish
TypePostprint
Formatapplication/pdf
SourceInsect Biochemistry. - 17 (1987), 7, pp. 1119-1122. - ISSN 0020-1790
Rightshttp://opus.kobv.de/ubp/doku/urheberrecht.php

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