Nowadays, cancer treatment and tissue regeneration have attracted large amount of attention. Single Wall Carbon Nanotubes (SWNT) possess large surface area and outstanding optical and electrical performance, making it a promising component in cancer therapy and tissue reengineering systems. In this study, four disease treating systems based on SWNT are developed. They are pH-sensitive poly(ethylene glycol)-doxorubicin(PEG-DOX)@SWNT drug release system, temperature sensitive SWNT hydrogel, SWNT based biocompatible magnetic hydrogel and biocompatible SWNT-gelatin-F127-cysteamine hydrogel for tissue engineering. The successfully synthesized target compounds are characterized by FTIR. The in vitro release of drugs from the drug release systems is evaluated upon changes of pH values and the laser scanning. The effect of cancer treatment systems on specific kind of cells are examined by confocal laser scanning microscopy (CLSM). The results indicate that all of the four systems show great potential in the biomedical applications especially in disease therapy applications.
| Identifer | oai:union.ndltd.org:MANITOBA/oai:mspace.lib.umanitoba.ca:1993/23149 |
| Date | January 2014 |
| Creators | Liu, Shuhan Jr |
| Contributors | Zhong, Wen (Textile Sciences) Xing, Malcolm (Mechanical Engineering), Kong, Jiming (Human Anatomy and Cell Science) Ko, Alex (National Research Council Canada) |
| Publisher | Journal of Materials Chemistry B |
| Source Sets | University of Manitoba Canada |
| Detected Language | English |
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