Sinteza 2',3'- dideoksinukleozida / The Synthesis of 2´, 3' - Dideoxynucleozides

Description

<p>U radu je ostvarena vi&scaron;efazna transformacija D-ksiloze u pogodno funkcionalizovane derivate koji su kuplovanjem sa siliranim timinom selektivno dali nukleozide sa beta-konfiguracijom na anomernom centru. Takođe, u cilju sinteze nukleozida L-serije, ispitana je mogućnost izomerizacije nekih derivata D-&scaron;ečera u odgovarajuće L-stereoizomere.</p> / <p>Muitistep transformation of D-xylose to suitabte functional derivatives were achieved. Coupling of these derivatives with silylated thymine gave the nucleosides with beta-configuration on anomeric centre. In order to synthesis nucleosides of L-series, the possibility for isomerization of some kinds D-sugar derivatives in corresponding L-stereisomeric compounds, were investigatet, too.</p>

Links & Downloads

1. https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija153777435546335.pdf?controlNumber=(BISIS)71445&fileName=153777435546335.pdf&id=11984&source=NDLTD&language=en
2. https://www.cris.uns.ac.rs/record.jsf?recordId=71445&source=NDLTD&language=en

Tags

Additional Fields

Identifer	oai:union.ndltd.org:uns.ac.rs/oai:CRISUNS:(BISIS)71445
Date	18 December 1998
Creators	Ćetković Gordana
Contributors	Lajšić Stevan, Milić Božidar, Popsavin Velimir
Publisher	Univerzitet u Novom Sadu, Tehnološki fakultet Novi Sad, University of Novi Sad, Faculty of Technology at Novi Sad
Source Sets	University of Novi Sad
Language	Serbian
Detected Language	English
Type	PhD thesis