To discover novel and bioactive secondary metabolites is a main
mission for natural product researchers. Soft corals of the genus Sinularia
were proved to yield a wide variety of secondary metabolites including
sesquiterpenoids, diterpenoids and steroids. In the thesis, the chemical
examinations on the organic extracts of the soft coral Sinularia capillosa
(collected at Dongsha Islands) resulted in the isolation of ten secondary
metabolites (1¡V10) including five new secondary metabolites (1¡V5) and
five known metabolites (6¡V10). The new secondary metabolites included
one new tetraprenylbenzoquinone (1), two furanobenzosesquiterpene (2,
3), one furanosesquiterpene (4), and a novel sesquiterpene (5). The
known metabolites included an acid-substituted furanosesquiterpene (6),
two furanobenzosesquiterpenes (7, 8), loliolide (9), and the known
sesequiterpene (10). The structures of the isolated secondary metabolites
were elucidated by 1H-NMR, 13C-NMR, COSY, HSQC, HMBC, NOESY,
IR, UV, CD, MS, and optical rotation. The cytotoxicities against cancer
cells, anti-inflammatory effects, and anti-HCMV (human
cytomegalovirus) activities of these isolated metabolites were evaluated.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0826109-120934 |
| Date | 26 August 2009 |
| Creators | Huang, Ke-jhih |
| Contributors | Ian-Lih Tsai, Chang-Yih Duh, Ling-Ching Chen |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0826109-120934 |
| Rights | not_available, Copyright information available at source archive |
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