Vitamin D status is assessed with circulating 25-hydroxyvitamin D [25(OH)D].
As some evidence suggests that low vitamin D status adversely affects neonatal health,
this project aimed to determine the association between cord blood 25(OH)D levels and
preterm birth (PTB; <37 weeks gestation), low birthweight (LBW; <2500 grams) and
small for gestational age (SGA; <10th percentile) and to examine the relationship between
maternal 25(OH)D levels during the first trimester of pregnancy and fetal 25(OH)D
levels at birth in a Canadian population.
This nested case-control study used serums, questionnaires and chart reviews
collected in Quebec City. Compared to 25(OH)D concentrations ≥75 nmol/L,
concentrations 37.5-<75, 50-<75, and <75 nmol/L were associated with lower odds of
LBW, PTB and an adverse neonatal composite outcome, and PTB as well as LBW,
respectively. Maternal and neonatal 25(OH)D were correlated (r=0.23, p<0.01; adjusted
r=0.46, p<0.01). This study contributes to evidence for identifying further policy and
research directions.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:NSHD.ca#10222/38668 |
| Date | 05 November 2013 |
| Creators | Morgan, Catherine |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
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