This study investigated the effects of SEA0400, a Na+/Ca2+ exchange inhibitor, in
cardioplegia on rat myocyte contractile function. SEA0400 significantly reduced the
accumulation of diastolic Ca2+ throughout cardioplegic arrest compared to ischemic
control and cardioplegia. Cells treated with SEA0400 during cardioplegic arrest showed
significantly larger Ca2+ transient amplitudes and contractions throughout reperfusion
compared to cells treated with cardiopelgia alone. Intracellular Ca2+ stores were similar in both cardioplegic groups at baseline and during reperfusion. Together these results suggest that SEA0400 has beneficial effects at protecting ventricular myocytes during cardioplegic arrest and that SEA0400 in cardioplegia may affect myofilament Ca2+ sensitivity.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:NSHD.ca#10222/35431 |
| Date | 06 August 2013 |
| Creators | Egar, Jeanne |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
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