Diversity-oriented synthesis (DOS) involves the synthesis of several synthetic targets by transforming a collection of structurally simple and similar starting materials into a collection of structurally more complex and diverse products. This thesis describes the elaboration of a 6,6-spiroacetal scaffold to incorporate biologically useful moieties, in particular nucleobases, triazoles and amino acids, thus generating a collection of novel hybrid structures. The research reported, herein, focused on the synthesis of spiroacetal-nucleosides, triazoles and amino acids bearing a C8′-hydroxymethyl substituent.
| Identifer | oai:union.ndltd.org:AUCKLAND/oai:researchspace.auckland.ac.nz:2292/2628 |
| Date | January 2008 |
| Creators | Choi, Ka Wai |
| Contributors | Professor Magaret Brimble |
| Publisher | ResearchSpace@Auckland |
| Source Sets | University of Auckland |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Rights | Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated., http://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm, Copyright: The author |
| Relation | PhD Thesis - University of Auckland, UoA1829830 |
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