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Recognition Tunneling: Approaches towards Next Generation DNA Sequencing

abstract: This thesis describes several approaches to next generation DNA sequencing via tunneling current method based on a Scanning Tunneling Microscope system. In chapters 5 and 6, preliminary results have shown that DNA bases could be identified by their characteristic tunneling signals. Measurements taken in aqueous buffered solution showed that single base resolution could be achieved with economic setups. In chapter 7, it is illustrated that some ongoing measurements are indicating the sequence readout by making linear scan on a piece of short DNA oligomer. However, to overcome the difficulties of controlling DNA especially ssDNA movement, it is much better to have the tunneling measurement incorporated onto a robust nanopore device to realize sequential reading of the DNA sequence while it is being translocated. / Dissertation/Thesis / Ph.D. Physics 2011

Identiferoai:union.ndltd.org:asu.edu/item:8943
Date January 2011
ContributorsHuang, Shuo (Author), Lindsay, Stuart (Advisor), Sankey, Otto (Committee member), Tao, Nongjian (Committee member), Drucker, Jeff (Committee member), Ros, Robert (Committee member), Arizona State University (Publisher)
Source SetsArizona State University
LanguageEnglish
Detected LanguageEnglish
TypeDoctoral Dissertation
Format150 pages
Rightshttp://rightsstatements.org/vocab/InC/1.0/, All Rights Reserved

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