Yes / Recent studies portend a rising global spread and adaptation of human- or healthcare- associated pathogens. Here, we analyse an international collection of the emerging, multi-drug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia
complex is divided into 23 monophyletic lineages, most of which harbour strains of all
degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated
strains, linked to key virulence and resistance genes. Transmission analysis identifies
potential outbreak events of genetically closely related strains isolated within days or weeks
in the same hospitals.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/17801 |
| Date | 05 May 2020 |
| Creators | Groschel, M.I., Meehan, Conor J., Barilar, I., Diricks, M., Gonzaga, A., Steglich, M., Conchillo-Solé, O., Scherer, I.-C., Mamat, U., Luz, C.F., De Bruyne, K., Utpatel, C., Yero, D., Gilbert, I., Daura, X., Kampmeier, S., Rahman1, N.A., Kresken, M., van der Werf, T.S., Alio, I., Streit, W.R., Zhou, K., Schwartz, Z., Rossen, J.W.A., Farhat, M.R., Schaible, U.E., Nübel, U., Rupp, J., Steinmann, J., Niemann, S., Kohl, T.A. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Published version |
| Rights | © 2020 The Authors. Published by Nature Publishing. This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0/, CC-BY |
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